Compound Detail
CHEMBL278630
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Basic Information
| ChEMBL ID | CHEMBL278630 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CNXDNYDEXTTZHT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
401.9
MW (Da)
5.19
ALogP
5
HBA
2
HBD
79.8
PSA (Ų)
0.48
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor CHEMBL2095189 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor | IC50 | = | 150.0 | nM | 6.82 | Inhibition of tyrosine kinase(PDGF-R) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(96)00197-7 | Platelet-derived growth factor receptor | 1 |
| - | 10.1016/0960-894X(96)00197-7 | Epidermal growth factor receptor | 1 |
| - | 10.1016/0960-894X(96)00197-7 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| - | 10.1016/0960-894X(96)00197-7 | Protein kinase C alpha type | 1 |
| - | 10.1016/0960-894X(96)00197-7 | Protein kinase C delta type | 1 |
| - | 10.1016/0960-894X(96)00197-7 | cAMP-dependent protein kinase (PKA) | 1 |
Data from ChEMBL 36 via Core Engine