Compound Detail
CHEMBL281732
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CCCCOP(=O)(CCCCC1(C(=O)NCCc2ccc(OC)cc2)c2ccccc2-c2ccccc21)OCCCC
Basic Information
| ChEMBL ID | CHEMBL281732 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BXIOVPPUNCIVFD-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
591.7
MW (Da)
8.32
ALogP
5
HBA
1
HBD
73.9
PSA (Ų)
0.12
QED
2
Ro5 Violations
18
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.64
IC50 1 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Microsomal triglyceride transfer protein large subunit CHEMBL2934 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
| HepG2 CHEMBL395 | EC50 | 7.64 | 7.64 | 23.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Microsomal triglyceride transfer protein large subunit | IC50 | = | 21.0 | nM | 7.68 | Inhibitory activity against microsomal triglyceride transfer protein (MTP) | 12657277 |
| HepG2 | EC50 | = | 23.0 | nM | 7.64 | Effective concentration against secretion of apolipoprotein B (ApoB) from HepG2 ... | 12657277 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12657277 | 10.1016/s0960-894x(03)00116-1 | HepG2 | 2 |
| 12657277 | 10.1016/s0960-894x(03)00116-1 | Microsomal triglyceride transfer protein large subunit | 1 |
| 12657277 | 10.1016/s0960-894x(03)00116-1 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine