Compound Detail
CHEMBL282709
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CCN1C(=O)c2c(nc(N=[N+]=[N-])n2Cc2ccc(O)cc2)N2C1=N[C@@H]1CCC[C@@H]12
Basic Information
| ChEMBL ID | CHEMBL282709 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MKBCATBOCWBEBI-KGLIPLIRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
392.4
MW (Da)
3.15
ALogP
7
HBA
1
HBD
122.7
PSA (Ų)
0.49
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 9.21 | 9.21 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 0.61 | nM | 9.21 | Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzyme | 14980684 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14980684 | 10.1016/j.bmcl.2003.12.027 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 14980684 | 10.1016/j.bmcl.2003.12.027 | Phosphodiesterases; PDE5 & PDE6 | 1 |
Data from ChEMBL 36 via Core Engine