Compound Detail
CHEMBL282805
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Basic Information
| ChEMBL ID | CHEMBL282805 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KEBJMSSIYOGESY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
443.5
MW (Da)
4.25
ALogP
6
HBA
1
HBD
90.2
PSA (Ų)
0.36
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 8.62 | 7.77 | 2.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C (PKC) | IC50 | = | 2.4 | nM | 8.62 | In vitro inhibition of protein kinase C from rat brain. | - |
| Protein kinase C (PKC) | IC50 | = | 120.0 | nM | 6.92 | In vitro inhibition of protein kinase C from rat brain. | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80356-5 | Protein kinase C (PKC) | 2 |
Data from ChEMBL 36 via Core Engine