Compound Detail
CHEMBL284424
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Basic Information
| ChEMBL ID | CHEMBL284424 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QHEJXFYXXWVDRL-CVEARBPZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
335.5
MW (Da)
2.10
ALogP
4
HBA
2
HBD
49.6
PSA (Ų)
0.81
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 7.17 | 7.17 | 68.0 | 1 |
| Rat1 CHEMBL614630 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 68.0 | nM | 7.17 | Inhibition of [3H]FPP incorporation into Ha-Ras by Farnesyltransferase | 8691462 |
| Rat1 | IC50 | = | 5000.0 | nM | 5.3 | Highest nontoxic concentration in RAT1 cells | 8691462 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8691462 | 10.1021/jm9508090 | Protein farnesyltransferase | 1 |
| 8691462 | 10.1021/jm9508090 | Rat1 | 1 |
Data from ChEMBL 36 via Core Engine