Compound Detail
CHEMBL297074
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Basic Information
| ChEMBL ID | CHEMBL297074 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UGVHKBFCVAPMRF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
440.5
MW (Da)
4.26
ALogP
8
HBA
1
HBD
103.6
PSA (Ų)
0.47
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 CHEMBL285 | IC50 | 6.35 | 6.35 | 450.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 | IC50 | = | 450.0 | nM | 6.35 | Liver ACAT inhibitory activity was determined in vitro using [1-14C]oleolyl-CoA ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(96)00310-1 | Sterol O-acyltransferase 1 | 1 |
| - | 10.1016/0960-894X(96)00310-1 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine