Compound Detail
CHEMBL303515
LOVASTATIN SODIUM Enter ChEMBL ID:
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CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CCC(O)C[C@@H](O)CC(=O)[O-])[C@H]21.[Na+]
Basic Information
| ChEMBL ID | CHEMBL303515 |
| Name | LOVASTATIN SODIUM |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LXZBFUBRYYVRQJ-ABAZHTNSSA-M |
| Parent Compound | CHEMBL1206749 |
| Active Moiety | CHEMBL1206749 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
422.6
MW (Da)
3.72
ALogP
5
HBA
3
HBD
104.1
PSA (Ų)
0.46
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase CHEMBL402 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | IC50 | = | 20.0 | nM | 7.7 | Tested in vitro for the inhibition of HMG-CoA reductase from partially purified ... | 1597859 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1597859 | 10.1021/jm00089a022 | No relevant target | 1 |
| 1597859 | 10.1021/jm00089a022 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1 |
Data from ChEMBL 36 via Core Engine