Compound Detail
CHEMBL304383
SARCOSINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL304383 |
| Name | SARCOSINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FSYKKLYZXJSNPZ-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
9
Publications
2
Known Names
4
Indications
Molecular Properties
89.1
MW (Da)
-0.71
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.47
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Depressive Disorder Depressive Disorder, Major Mental Disorders Schizophrenia
Activity Summary
IC50 2 meas. best 4.04
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium- and chloride-dependent glycine transporter 1 CHEMBL2337 | IC50 | 4.04 | 4.04 | 91000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium- and chloride-dependent glycine transporter 1 | IC50 | = | 91000.0 | nM | 4.04 | Inhibition of human GlyT-1 | 28876062 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 21955456 | 10.1016/j.bmc.2011.08.058 | Proton-coupled amino acid transporter 1 | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 2549245 | 10.1021/jm00129a016 | Unchecked | 1 |
| 3965711 | 10.1021/jm00379a002 | No relevant target | 1 |
| 28876062 | 10.1021/acs.jmedchem.7b00956 | Sodium- and chloride-dependent glycine transporter 1 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine