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Compound Detail

CHEMBL305666

LURTOTECAN
🧪 Phase II
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🧪 Phase II
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc3c(cc1c2CN1CCN(C)CC1)OCCO3
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL305666
Name LURTOTECAN
Phase Phase II
Structure Type MOL
InChI Key RVFGKBWWUQOIOU-NDEPHWFRSA-N

Known Names

Lurtotecan
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
2
Publications
1
Known Names
7
Indications

Molecular Properties

518.6
MW (Da)
1.60
ALogP
10
HBA
1
HBD
106.4
PSA (Ų)
0.40
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product
USAN Stem -tecan
USAN Year 1996

Extended Properties

Molecular Formula C28H30N4O6
MW 518.57
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness 0.32

Indications

Fallopian Tube Neoplasms Head and Neck Neoplasms Ovarian Neoplasms Ovarian Neoplasms Peritoneal Neoplasms Small Cell Lung Carcinoma Neoplasms

Literature References

PubMed DOI Target Context # Activities
11309344 - Broad substrate specificity ATP-binding cassette transporter ABCG2 2
9632354 10.1021/jm9605445 DNA topoisomerase 1 1

Data from ChEMBL 36 via Core Engine