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Compound Detail

CHEMBL3084396

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CN1[C@@H]2CC[C@H]1C[C@@H](CC(O)(c1cccs1)c1cccs1)C2

Basic Information

ChEMBL ID CHEMBL3084396
Phase Preclinical
Structure Type MOL
InChI Key ZWDDMBUPVUAOHG-QDMKHBRRSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

333.5
MW (Da)
4.31
ALogP
4
HBA
1
HBD
23.5
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H23NOS2
MW 333.52
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.05

Activity Summary

Kd 1 meas. best 8.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
Kd 8.6 8.6 2.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19630384 10.1021/jm900736e Muscarinic acetylcholine receptor M3 2
19630384 10.1021/jm900736e Mus musculus 1

Data from ChEMBL 36 via Core Engine