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Compound Detail

CHEMBL3084410

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C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](CC(O)(c1cccs1)c1cccs1)C2.[Br-]

Basic Information

ChEMBL ID CHEMBL3084410
Phase Preclinical
Structure Type MOL
InChI Key VKVBLOMSVSKUIE-ZIGIEQIVSA-M
Parent Compound CHEMBL3140099
Active Moiety CHEMBL3140099
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

348.6
MW (Da)
4.45
ALogP
3
HBA
1
HBD
20.2
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H26BrNOS2
MW 428.46
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.10

Activity Summary

Kd 1 meas. best 8.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
Kd 8.6 8.6 2.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19630384 10.1021/jm900736e Muscarinic acetylcholine receptor M3 2
19630384 10.1021/jm900736e Mus musculus 1

Data from ChEMBL 36 via Core Engine