Compound Detail
CHEMBL308759
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Basic Information
| ChEMBL ID | CHEMBL308759 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UXUZARPLRQRNNX-DXTOWSMRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
17
Publications
0
Known Names
Molecular Properties
285.2
MW (Da)
-1.30
ALogP
9
HBA
4
HBD
139.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.18 | 5.18 | 6600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 6600.0 | nM | 5.18 | Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells ... | 25978965 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4513161 | Pseudomonas aeruginosa | 2 |
| - | 10.6019/CHEMBL4513161 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513161 | HEK293 | 1 |
| - | 10.6019/CHEMBL4513161 | Erythrocyte | 1 |
| - | 10.6019/CHEMBL4513161 | Staphylococcus aureus | 1 |
| - | 10.6019/CHEMBL4513161 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4513161 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4513161 | Escherichia coli | 1 |
| 15084127 | 10.1021/jm030424e | Hepatitis C virus | 1 |
| - | 10.6019/CHEMBL4513161 | Candida albicans | 1 |
| 25978965 | 10.1016/j.bmcl.2015.04.073 | MT4 | 1 |
| 25978965 | 10.1016/j.bmcl.2015.04.073 | DNA polymerase subunit gamma-1/gamma-2 | 1 |
| 25978965 | 10.1016/j.bmcl.2015.04.073 | DNA-directed RNA polymerase, mitochondrial | 1 |
| 25978965 | 10.1016/j.bmcl.2015.04.073 | NON-PROTEIN TARGET | 1 |
| 25978965 | 10.1016/j.bmcl.2015.04.073 | Unchecked | 1 |
| 15084127 | 10.1021/jm030424e | RNA-directed RNA polymerase | 1 |
Data from ChEMBL 36 via Core Engine