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Compound Detail

CHEMBL3092407

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O=C(C[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O)Nc1ccc(O)cc1

Basic Information

ChEMBL ID CHEMBL3092407
Phase Preclinical
Structure Type MOL
InChI Key ZUNIPPVNLLIJNF-OMRXRXQOSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

313.3
MW (Da)
-1.44
ALogP
7
HBA
6
HBD
139.5
PSA (Ų)
0.37
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H19NO7
MW 313.31
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness 0.48

Activity Summary

Kd 1 meas. best 6.48

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 6.48 6.48 328.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 328.0 nM 6.48 Binding affinity to Escherichia coli J96 FimH lectin domain (Phe1 to Thr158) exp... 24900609

Literature References

PubMed DOI Target Context # Activities
24900609 10.1021/ml400269v Unchecked 1

Data from ChEMBL 36 via Core Engine