Compound Detail
CHEMBL310276
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CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(COCc3ccc4ccccc4n3)cc12
Basic Information
| ChEMBL ID | CHEMBL310276 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJCJJFAHBCPZIB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
601.2
MW (Da)
9.15
ALogP
5
HBA
1
HBD
64.3
PSA (Ų)
0.16
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arachidonate 5-lipoxygenase-activating protein CHEMBL4550 | IC50 | 7.58 | 7.58 | 26.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arachidonate 5-lipoxygenase-activating protein | IC50 | = | 26.0 | nM | 7.58 | Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase act... | 10476875 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10476875 | 10.1016/s0960-894x(99)00399-6 | Homo sapiens | 2 |
| 10476875 | 10.1016/s0960-894x(99)00399-6 | Arachidonate 5-lipoxygenase-activating protein | 1 |
Data from ChEMBL 36 via Core Engine