Compound Detail
CHEMBL312225
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Basic Information
| ChEMBL ID | CHEMBL312225 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WJUGGKGTCAVATA-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
343.5
MW (Da)
4.25
ALogP
3
HBA
0
HBD
18.8
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.12
IC50 1 meas. best 5.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| SARS-CoV-2 CHEMBL4303835 | EC50 | 6.12 | 6.12 | 750.0 | 1 |
| Platelet-activating factor receptor CHEMBL250 | IC50 | 5.12 | 5.12 | 7500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SARS-CoV-2 | EC50 | = | 750.0 | nM | 6.12 | Determination of antiviral efficacy in high-content imaging assay in Vero E6 cel... | - |
| Platelet-activating factor receptor | IC50 | = | 7500.0 | nM | 5.12 | Inhibition of [3H]PAF binding to human platelet activating factor receptor | 7830265 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7830265 | 10.1021/jm00002a004 | Mus musculus | 10 |
| 7830265 | 10.1021/jm00002a004 | Abelson 8.1 | 3 |
| 7830265 | 10.1021/jm00002a004 | YAC-1 | 3 |
| 7830265 | 10.1021/jm00002a004 | Platelet-activating factor receptor | 1 |
| - | 10.1101/2020.04.16.044016 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine