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Compound Detail

CHEMBL312916

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CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Basic Information

ChEMBL ID CHEMBL312916
Phase Preclinical
Structure Type BOTH
InChI Key KSMIQAULFAKWPP-VIPNTURPSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

619.8
MW (Da)
3.09
ALogP
5
HBA
6
HBD
169.5
PSA (Ų)
0.14
QED
2
Ro5 Violations
16
Rot. Bonds

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H45N5O6
MW 619.76
Aromatic Rings 3
Heavy Atoms 45
NP-Likeness 0.01

Literature References

PubMed DOI Target Context # Activities
8410970 10.1021/jm00070a001 Endothelin-1 receptor 1
8410970 10.1021/jm00070a001 Endothelin receptor type B 1
- 10.1016/S0960-894X(01)81215-4 Endothelin-1 receptor 1
- 10.1016/S0960-894X(01)81215-4 Endothelin receptor type B 1
- 10.1016/S0960-894X(01)81215-4 Oryctolagus cuniculus 1

Data from ChEMBL 36 via Core Engine