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Compound Detail

CHEMBL3142420

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Cc1cn([C@H]2C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CO)O2)c(=O)[nH]c1=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3142420
Phase Preclinical
Structure Type MOL
InChI Key QAPSNMNOIOSXSQ-YNEHKIRRSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

356.5
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H28N2O5Si
MW 356.50

Activity Summary

EC50 2 meas. best 4.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
C8166
CHEMBL614533
 EC50 4.8 4.8 16000.0 1
JM1
CHEMBL614589
 EC50 4.7 4.7 20000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
C8166 EC50 = 16000.0 nM 4.8 Anti-HIV activity against HIV-1 infected C8166 cell lines -
JM1 EC50 = 20000.0 nM 4.7 Anti-HIV activity against HIV-1 infected JM cell lines -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(96)00443-X C8166 2
- 10.1016/0960-894X(96)00443-X JM1 2

Data from ChEMBL 36 via Core Engine