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Compound Detail

CHEMBL314742

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Nc1nc(O)c2ncn(C[C@H](CCO)OCP(=O)(O)O)c2n1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL314742
Phase Preclinical
Structure Type MOL
InChI Key OJMOYLBKUNUXMP-LURJTMIESA-N
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

333.2
MW (Da)
-0.98
ALogP
9
HBA
5
HBD
176.8
PSA (Ų)
0.40
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H16N5O6P
MW 333.24
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.08

Activity Summary

IC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
8410987 10.1021/jm00071a003 Human betaherpesvirus 5 2
8410987 10.1021/jm00071a003 Human alphaherpesvirus 2 2
8410987 10.1021/jm00071a003 Human immunodeficiency virus 1 1
8410987 10.1021/jm00071a003 CCRF-CEM 1

Data from ChEMBL 36 via Core Engine