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Compound Detail

CHEMBL315203

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N[C@H](Cc1c(O)noc1-c1ccccc1)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL315203
Phase Preclinical
Structure Type MOL
InChI Key JCXLPVAAGYNKBT-SECBINFHSA-N
0
Targets
2
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

248.2
MW (Da)
1.00
ALogP
5
HBA
3
HBD
109.6
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H12N2O4
MW 248.24
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness 0.14

Activity Summary

EC50 1 meas.
Ki 1 meas.

Literature References

PubMed DOI Target Context # Activities
9651156 10.1021/jm9801206 Glutamate receptor ionotropic, AMPA 2
7512140 10.1021/jm00033a003 Glutamate receptor ionotropic, AMPA 2
7512140 10.1021/jm00033a003 Glutamate NMDA receptor 2
9651156 10.1021/jm9801206 Glutamate receptor ionotropic, kainate 1
9651156 10.1021/jm9801206 Glutamate NMDA receptor 1
7512140 10.1021/jm00033a003 Glutamate receptor ionotropic, kainate 1
7512140 10.1021/jm00033a003 Glutamate receptor ionotropic, NMDA 1 1

Data from ChEMBL 36 via Core Engine