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Compound Detail

CHEMBL319096

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CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCCc1ccccc1

Basic Information

ChEMBL ID CHEMBL319096
Phase Preclinical
Structure Type MOL
InChI Key TVQLWHYXBOTZLE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

475.0
MW (Da)
5.30
ALogP
2
HBA
4
HBD
86.0
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H27ClN4O2
MW 474.99
Aromatic Rings 4
Heavy Atoms 34
NP-Likeness -0.89

Activity Summary

Ki 1 meas. best 5.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cholecystokinin receptor type A
CHEMBL3501
Ki 5.2 5.2 6329.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8411002 10.1021/jm00072a005 Gastrin/cholecystokinin type B receptor 1
8411002 10.1021/jm00072a005 Cholecystokinin receptor type A 1

Data from ChEMBL 36 via Core Engine