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Compound Detail

CHEMBL319186

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CS(=O)(=O)Nc1cc([C@@H](O)CN[C@H](Cc2ccccc2)c2ccc(CC(N)=O)cc2)ccc1O

Basic Information

ChEMBL ID CHEMBL319186
Phase Preclinical
Structure Type MOL
InChI Key BPCMUCQPFCDFRH-QPPBQGQZSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

483.6
MW (Da)
2.40
ALogP
6
HBA
5
HBD
141.8
PSA (Ų)
0.27
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H29N3O5S
MW 483.59
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.60

Activity Summary

Ki 1 meas. best 7.13

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
Ki 7.13 7.13 74.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11714606 10.1016/s0960-894x(01)00629-1 Beta-3 adrenergic receptor 2
11714606 10.1016/s0960-894x(01)00629-1 Beta-2 adrenergic receptor and beta-3 adrenergic receptor 1
11714606 10.1016/s0960-894x(01)00629-1 Adrenergic receptor beta; ADRB1 & ADRB3 1

Data from ChEMBL 36 via Core Engine