Compound Detail
CHEMBL321272
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Basic Information
| ChEMBL ID | CHEMBL321272 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FCZCDBTWWAPZRL-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
245.2
MW (Da)
0.26
ALogP
7
HBA
3
HBD
126.6
PSA (Ų)
0.52
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.09
Ki 1 meas. best 4.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 4.36 | 4.36 | 44000.0 | 1 |
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | IC50 | 4.09 | 4.09 | 81000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 44000.0 | nM | 4.36 | Binding affinity at ionotropic glutamate receptor AMPA in rat cortical membranes... | 11543685 |
| Glutamate receptor ionotropic, kainate | IC50 | = | 81000.0 | nM | 4.09 | Inhibition of [3H]KA binding to kainate receptor of rat brain membranes | 11543685 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, AMPA | 1 |
| 11543685 | 10.1021/jm010862q | Glutamate NMDA receptor | 1 |
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, kainate | 1 |
Data from ChEMBL 36 via Core Engine