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Compound Detail

CHEMBL3216717

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Cc1c(C)c2c(c(C)c1O)CC[C@](C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2.Cl.Cl

Basic Information

ChEMBL ID CHEMBL3216717
Phase Preclinical
Structure Type MOL
InChI Key KJGXSMZHYBXPIS-ZHXNKHNVSA-N
Parent Compound CHEMBL604119
Active Moiety CHEMBL604119
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

520.7
MW (Da)
4.21
ALogP
8
HBA
1
HBD
68.2
PSA (Ų)
0.63
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H46Cl2N6O2
MW 593.64
Aromatic Rings 2
Heavy Atoms 38
NP-Likeness -0.08

Activity Summary

IC50 2 meas. best 4.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycolicibacterium smegmatis
CHEMBL613088
IC50 4.46 4.46 34250.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19786608 10.1128/aac.00803-09 Mycolicibacterium smegmatis 12
17417631 10.1038/nchembio873 Unchecked 1

Data from ChEMBL 36 via Core Engine