Compound Detail
CHEMBL3235261
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Basic Information
| ChEMBL ID | CHEMBL3235261 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CPFPYUXWODTTEC-MOPGFXCFSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
415.5
MW (Da)
2.76
ALogP
6
HBA
1
HBD
84.1
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Orexin receptor type 2 CHEMBL4792 | Ki | 7.38 | 7.38 | 42.0 | 1 |
| Orexin/Hypocretin receptor type 1 CHEMBL5113 | Ki | 7.12 | 7.12 | 76.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Orexin receptor type 2 | Ki | = | 42.0 | nM | 7.38 | Binding affinity to human OX2 receptor in cell membrane by in vitro radioligand ... | 24630562 |
| Orexin/Hypocretin receptor type 1 | Ki | = | 76.0 | nM | 7.12 | Binding affinity to human OX1 receptor in cell membrane by in vitro radioligand ... | 24630562 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24630562 | 10.1016/j.bmcl.2014.02.026 | Orexin receptor type 2 | 2 |
| 24630562 | 10.1016/j.bmcl.2014.02.026 | Orexin/Hypocretin receptor type 1 | 2 |
Data from ChEMBL 36 via Core Engine