Compound Detail
CHEMBL3237431
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Basic Information
| ChEMBL ID | CHEMBL3237431 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZOYGIVRWNMMNF-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
417.5
MW (Da)
5.16
ALogP
6
HBA
1
HBD
60.2
PSA (Ų)
0.49
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 7.47 | 6.74 | 34.0 | 2 |
| Glycylpeptide N-tetradecanoyltransferase CHEMBL2169722 | Ki | 7.01 | 7.01 | 98.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 34.0 | nM | 7.47 | Inhibition of Plasmodium vivax N-myristoyltransferase by CPM fluorescence assay | 24641010 |
| Glycylpeptide N-tetradecanoyltransferase | Ki | = | 98.0 | nM | 7.01 | Inhibition of Plasmodium falciparum N-myristoyltransferase by CPM fluorescence a... | 24641010 |
| Unchecked | Ki | = | 976.0 | nM | 6.01 | Inhibition of human N-myristoyltransferase using H-Gly-Ser-Asn-Lys-Ser-Lys-Pro-L... | 24641010 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24641010 | 10.1021/jm500066b | Unchecked | 2 |
| 24641010 | 10.1021/jm500066b | Glycylpeptide N-tetradecanoyltransferase | 1 |
| 24641010 | 10.1021/jm500066b | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine