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Compound Detail

CHEMBL3264790

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CC1(C)CC(NC(=O)c2ccc(Oc3ccccc3C#N)c(Cl)c2)C(F)(F)C(C)(C)N1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3264790
Phase Preclinical
Structure Type MOL
InChI Key LZPASDWYMILSCV-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

447.9
MW (Da)
5.29
ALogP
4
HBA
2
HBD
74.2
PSA (Ų)
0.67
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H24ClF2N3O2
MW 447.91
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -0.97

Literature References

PubMed DOI Target Context # Activities
24900844 10.1021/ml400494b Histone-lysine N-methyltransferase EZH2 2

Data from ChEMBL 36 via Core Engine