Compound Detail
CHEMBL3274344
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3274344 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NMAPMZGVYBPUKX-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
194.2
MW (Da)
2.25
ALogP
3
HBA
2
HBD
57.5
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 2.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C iota type CHEMBL2598 | IC50 | 2.81 | 2.81 | 1556000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C iota type | IC50 | = | 1556000.0 | nM | 2.81 | Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in bacul... | 29688013 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 926120 | 10.1021/jm00219a017 | Unchecked | 2 |
| 926120 | 10.1021/jm00219a017 | Rattus norvegicus | 2 |
| 29688013 | 10.1021/acs.jmedchem.8b00060 | Protein kinase C iota type | 1 |
Data from ChEMBL 36 via Core Engine