Compound Detail
CHEMBL3289423
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Basic Information
| ChEMBL ID | CHEMBL3289423 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NAZSUSPAXCYQQA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
2.68
ALogP
5
HBA
1
HBD
66.7
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA-directed RNA polymerase I subunit RPA1 CHEMBL3286067 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.8 | 6.8 | 160.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.9 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA-directed RNA polymerase I subunit RPA1 | IC50 | = | 110.0 | nM | 6.96 | Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells aft... | 24847734 |
| Unchecked | IC50 | = | 160.0 | nM | 6.8 | Inhibition of RNA polymerase-1 in human U2OS cells assessed as decrease in nucle... | 24847734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24847734 | 10.1021/jm5004842 | Unchecked | 3 |
| 24847734 | 10.1021/jm5004842 | DNA-directed RNA polymerase I subunit RPA1 | 2 |
| 24847734 | 10.1021/jm5004842 | Liver microsome | 1 |
Data from ChEMBL 36 via Core Engine