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Compound Detail

CHEMBL33

LEVOFLOXACIN ANHYDROUS
💊 Approved Drug
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💊 Approved Drug
C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL33
Name LEVOFLOXACIN ANHYDROUS
Phase Approved
Structure Type MOL
InChI Key GSDSWSVVBLHKDQ-JTQLQIEISA-N
Therapeutic ✓ Yes

Known Names

Levofloxacin (anhydrous) Levofloxacin anhydrous Levofloxacine (anhydrous) Levofloxacino (anhydrous) NSC-758709 Ofloxacin s-(-)-form
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
6
Known Names
4
Indications

Molecular Properties

361.4
MW (Da)
1.54
ALogP
6
HBA
1
HBD
75.0
PSA (Ų)
0.87
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1996
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral Parenteral Topical

Flags

Black Box Warning
USAN Stem -oxacin
USAN Year 1996

Extended Properties

Molecular Formula C18H20FN3O4
MW 361.37
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.21

Indications

Infections Tuberculosis Urinary Bladder, Overactive Osteomyelitis

Literature References

PubMed DOI Target Context # Activities
37659197 10.1016/j.ejmech.2023.115757 Staphylococcus aureus 15
37360391 10.1039/d3md00017f Staphylococcus aureus 14
38665829 10.1039/d4md00062e Staphylococcus aureus 14
37484564 10.1039/d3md00079f Staphylococcus aureus 14
37731699 10.1039/d3md00290j Staphylococcus aureus 13
37399709 10.1016/j.ejmech.2023.115579 Mycobacterium tuberculosis 10
37731699 10.1039/d3md00290j Enterococcus faecalis 8
37698518 10.1021/acs.jmedchem.3c00891 Staphylococcus aureus 8
39232465 10.1016/j.bmc.2024.117901 Staphylococcus aureus 7
38482826 10.1021/acs.jmedchem.3c02197 Staphylococcus aureus 5
37116266 10.1016/j.ejmech.2023.115351 Mycobacterium tuberculosis 5
37672933 10.1016/j.ejmech.2023.115778 Escherichia coli 4
37672933 10.1016/j.ejmech.2023.115778 Klebsiella pneumoniae 4
37862150 10.1021/acs.jnatprod.3c00628 Staphylococcus aureus 3
37698518 10.1021/acs.jmedchem.3c00891 Acinetobacter baumannii 3
38482826 10.1021/acs.jmedchem.3c02197 Streptococcus pneumoniae 3
38482826 10.1021/acs.jmedchem.3c02197 Enterococcus faecium 3
37698518 10.1021/acs.jmedchem.3c00891 Escherichia coli 3
28288109 10.1038/nchembio.2334 Mas-related G-protein coupled receptor member X2 3
38482826 10.1021/acs.jmedchem.3c02197 Enterococcus faecalis 2

Data from ChEMBL 36 via Core Engine