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Compound Detail

CHEMBL3317785

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Cc1cccc2nc(-c3ccc(C(=O)N/N=C/c4cc(O)cc(O)c4)cc3)[nH]c12

Basic Information

ChEMBL ID CHEMBL3317785
Phase Preclinical
Structure Type MOL
InChI Key PIMKVHXWESJRDT-FSJBWODESA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

386.4
MW (Da)
3.71
ALogP
5
HBA
4
HBD
110.6
PSA (Ų)
0.32
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H18N4O3
MW 386.41
Aromatic Rings 4
Heavy Atoms 29
NP-Likeness -1.08

Activity Summary

IC50 3 meas. best 4.76

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
No relevant target
CHEMBL2362975
IC50 4.76 4.405 17300.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25069019 10.1016/j.ejmech.2014.07.078 No relevant target 3
25069019 10.1016/j.ejmech.2014.07.078 Leishmania major 1
25069019 10.1016/j.ejmech.2014.07.078 ADMET 1

Data from ChEMBL 36 via Core Engine