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Compound Detail

CHEMBL3327018

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F[P-](F)(F)(F)(F)F.[Na+]
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3327018
Phase Preclinical
Structure Type MOL
InChI Key KMADQUOCJBLXRP-UHFFFAOYSA-N
1
Targets
12
Activities
2
Assay Types
0
PK Parameters
19
Publications
0
Known Names

Molecular Properties

167.9
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula F6NaP
MW 167.95

Activity Summary

Ki 11 meas.
IC50 1 meas. best 8.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sodium/iodide cotransporter
CHEMBL2331047
 IC50 8.05 8.05 9.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Sodium/iodide cotransporter IC50 = 9.0 nM 8.05 Inhibition of sodium iodide symporter in rat FRTL5 cells assessed as decrease in... -

Literature References

PubMed DOI Target Context # Activities
27914949 10.1016/j.bmc.2016.11.021 Unchecked 4
26145820 10.1016/j.bmc.2015.06.021 Unchecked 3
28754318 10.1016/j.bmc.2017.07.033 Unchecked 2
28238511 10.1016/j.bmc.2017.02.032 Unchecked 2
25168748 10.1016/j.bmcl.2014.08.014 Unchecked 2
25168748 10.1016/j.bmcl.2014.08.014 Carbonic anhydrase 2 1
15780631 10.1016/j.bmcl.2005.01.082 Carbonic anhydrase 9 1
26145820 10.1016/j.bmc.2015.06.021 Carbonic anhydrase 2 1
26145820 10.1016/j.bmc.2015.06.021 Carbonic anhydrase 1
15780631 10.1016/j.bmcl.2005.01.082 Carbonic anhydrase 5A, mitochondrial 1
26068018 10.1016/j.bmc.2015.05.029 Carbonic anhydrase 1
26778292 10.1016/j.bmc.2016.01.005 Unchecked 1
27914949 10.1016/j.bmc.2016.11.021 Carbonic anhydrase 2 1
27914949 10.1016/j.bmc.2016.11.021 Carbonic anhydrase 1
15780631 10.1016/j.bmcl.2005.01.082 Carbonic anhydrase 4 1
28238511 10.1016/j.bmc.2017.02.032 Carbonic anhydrase 2 1
15780631 10.1016/j.bmcl.2005.01.082 Carbonic anhydrase 2 1
28754318 10.1016/j.bmc.2017.07.033 Carbonic anhydrase 2 1
15780631 10.1016/j.bmcl.2005.01.082 Carbonic anhydrase 1 1

Data from ChEMBL 36 via Core Engine