Compound Detail
CHEMBL333640
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL333640 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SYXUIDNWCZVPRH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
484.6
MW (Da)
5.65
ALogP
7
HBA
0
HBD
51.9
PSA (Ų)
0.24
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.72 | 7.72 | 19.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 19.0 | nM | 7.72 | Inhibition of Vascular endothelial growth factor receptor 2 | 12443771 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor 2 | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta) | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor 2 and 3 (KDR and Flt-4) | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | VEGF-receptor 2 and tyrosine-protein kinase SRC | 1 |
Data from ChEMBL 36 via Core Engine