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Compound Detail

CHEMBL3342129

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COc1ccc(C(=O)c2sc3nc(N)c(C#N)c(-c4cc(OC)c(OC)c(OC)c4)c3c2N)cc1

Basic Information

ChEMBL ID CHEMBL3342129
Phase Preclinical
Structure Type MOL
InChI Key BXMSLNBBJUZYAC-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

490.5
MW (Da)
4.26
ALogP
10
HBA
2
HBD
142.7
PSA (Ų)
0.36
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H22N4O5S
MW 490.54
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -0.95

Literature References

PubMed DOI Target Context # Activities
25311564 10.1016/j.bmc.2014.09.023 Unchecked 1
25311564 10.1016/j.bmc.2014.09.023 Multidrug resistance-associated protein 1 1
25311564 10.1016/j.bmc.2014.09.023 Broad substrate specificity ATP-binding cassette transporter ABCG2 1

Data from ChEMBL 36 via Core Engine