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Compound Detail

CHEMBL3342898

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C[C@]12CC[C@H](OC(=O)C3CCC3)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3ccnc3)=C(C=O)C[C@@H]12

Basic Information

ChEMBL ID CHEMBL3342898
Phase Preclinical
Structure Type MOL
InChI Key ZRTXIAQHQGBTMK-UAGBHOFDSA-N
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

448.6
MW (Da)
5.58
ALogP
5
HBA
0
HBD
61.2
PSA (Ų)
0.34
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H36N2O3
MW 448.61
Aromatic Rings 1
Heavy Atoms 33
NP-Likeness 0.83

Activity Summary

IC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
25261928 10.1016/j.bmc.2014.08.019 3-oxo-5-alpha-steroid 4-dehydrogenase 1 1
25261928 10.1016/j.bmc.2014.08.019 3-oxo-5-alpha-steroid 4-dehydrogenase 2 1
25261928 10.1016/j.bmc.2014.08.019 Androgen receptor 1
25261928 10.1016/j.bmc.2014.08.019 NON-PROTEIN TARGET 1
25261928 10.1016/j.bmc.2014.08.019 ADMET 1

Data from ChEMBL 36 via Core Engine