Compound Detail
CHEMBL3344393
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Basic Information
| ChEMBL ID | CHEMBL3344393 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JNCMZCZFSIAVQJ-BQYQJAHWSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
387.5
MW (Da)
5.12
ALogP
5
HBA
0
HBD
41.2
PSA (Ų)
0.39
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.85
Ki 2 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CHEMBL3329080 | Ki | 7.66 | 7.66 | 22.0 | 1 |
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial CHEMBL4521 | Ki | 7.51 | 7.51 | 31.0 | 1 |
| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CHEMBL3329080 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial CHEMBL4521 | IC50 | 6.36 | 6.36 | 440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | Ki | = | 22.0 | nM | 7.66 | Inhibition of mouse CYP27B1 by cell-free assay | 25240094 |
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | Ki | = | 31.0 | nM | 7.51 | Inhibition of N-terminally MBP-fused human CYP24A1 by cell-free assay | 25240094 |
| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | IC50 | = | 140.0 | nM | 6.85 | Inhibition of mouse CYP27B1 by cell-free assay | 25240094 |
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | IC50 | = | 440.0 | nM | 6.36 | Inhibition of N-terminally MBP-fused human CYP24A1 by cell-free assay | 25240094 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25240094 | 10.1016/j.ejmech.2014.09.035 | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | 2 |
| 25240094 | 10.1016/j.ejmech.2014.09.035 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | 2 |
| 25240094 | 10.1016/j.ejmech.2014.09.035 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine