Compound Detail
CHEMBL334830
RANIRESTAT 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL334830 |
| Name | RANIRESTAT |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | QCVNMNYRNIMDKV-QGZVFWFLSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
2
Known Names
2
Indications
Molecular Properties
420.2
MW (Da)
1.31
ALogP
5
HBA
1
HBD
88.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Diabetic Neuropathies Polyneuropathies
Activity Summary
IC50 2 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 CHEMBL1900 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Aldo-keto reductase family 1 member B1 CHEMBL4559 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | IC50 | = | 15.0 | nM | 7.82 | In vitro inhibitory activity against aldose reductase in porcine lens. | 9767647 |
| Aldo-keto reductase family 1 member B1 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of aldose reductase | 17870536 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 9767647 | 10.1021/jm9802968 | Aldo-keto reductase family 1 member B1 | 1 |
| 9767647 | 10.1021/jm9802968 | Rattus norvegicus | 1 |
| 17870536 | 10.1016/j.bmc.2007.08.019 | Aldo-keto reductase family 1 member B1 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine