Compound Detail
CHEMBL3393526
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Basic Information
| ChEMBL ID | CHEMBL3393526 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UAOJUVSUWLARMX-GFCCVEGCSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
248.4
MW (Da)
1.95
ALogP
4
HBA
2
HBD
40.2
PSA (Ų)
0.84
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.77
Kd 1 meas. best 9.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL3759 | Kd | 9.2 | 9.2 | 0.6 | 1 |
| Histamine H4 receptor CHEMBL3759 | Ki | 8.77 | 8.735 | 1.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H4 receptor | Kd | = | 0.631 | nM | 9.2 | Antagonist activity at human recombinant histamine H4 receptor expressed in SK-N... | 25595684 |
| Histamine H4 receptor | Ki | = | 1.7 | nM | 8.77 | Binding Assay: Cell pellets from SK-N-MC cells stably or transiently transfected... | - |
| Histamine H4 receptor | Ki | = | 2.0 | nM | 8.7 | Displacement of [3H]histamine from human recombinant histamine H4 receptor | 25595684 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25595684 | 10.1016/j.bmcl.2014.12.027 | Histamine H4 receptor | 2 |
Data from ChEMBL 36 via Core Engine