Compound Detail
CHEMBL339621
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Basic Information
| ChEMBL ID | CHEMBL339621 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BVBMPXYNTVNBOJ-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
387.6
MW (Da)
2.71
ALogP
4
HBA
1
HBD
52.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.2
IC50 1 meas. best 7.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Delta-type opioid receptor CHEMBL236 | IC50 | 7.42 | 7.42 | 37.9 | 1 |
| Delta-type opioid receptor CHEMBL236 | EC50 | 6.2 | 6.2 | 635.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | IC50 | = | 37.89 | nM | 7.42 | Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-del... | 11052793 |
| Delta-type opioid receptor | EC50 | = | 635.0 | nM | 6.2 | Agonist potency was measured using GTP gamma-[35S] binding assay | 11052793 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11052793 | 10.1021/jm000228x | Delta-type opioid receptor | 2 |
| 11052793 | 10.1021/jm000228x | ADMET | 1 |
Data from ChEMBL 36 via Core Engine