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Compound Detail

CHEMBL3403504

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COc1cccc(OC)c1-c1cc(CN[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12

Basic Information

ChEMBL ID CHEMBL3403504
Phase Preclinical
Structure Type MOL
InChI Key UCPIZCJXHXRCNC-NDEPHWFRSA-N
0
Targets
0
Activities
0
Assay Types
2
PK Parameters
2
Publications
0
Known Names

Molecular Properties

535.0
MW (Da)
5.88
ALogP
7
HBA
2
HBD
98.5
PSA (Ų)
0.28
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H31ClN4O4
MW 535.04
Aromatic Rings 4
Heavy Atoms 38
NP-Likeness -0.68

Pharmacokinetic Data

Parameter Value Units Species
Ke - - Rattus norvegicus
Ke - - Rattus norvegicus

Literature References

PubMed DOI Target Context # Activities
25881832 10.1016/j.bmcl.2015.03.083 Neurotensin receptor type 2 3
25881832 10.1016/j.bmcl.2015.03.083 Neurotensin receptor type 1 2

Data from ChEMBL 36 via Core Engine