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Compound Detail

CHEMBL3403603

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O=C(O)CCNCc1cn(CCOC(c2ccc(C(F)(F)F)cc2)c2ccc(C(F)(F)F)cc2)nn1

Basic Information

ChEMBL ID CHEMBL3403603
Phase Preclinical
Structure Type MOL
InChI Key SQRUDVQTSIEPIT-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

516.4
MW (Da)
4.69
ALogP
6
HBA
2
HBD
89.3
PSA (Ų)
0.28
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H22F6N4O3
MW 516.44
Aromatic Rings 3
Heavy Atoms 36
NP-Likeness -1.11

Literature References

PubMed DOI Target Context # Activities
25882526 10.1016/j.bmc.2015.03.060 Sodium- and chloride-dependent GABA transporter 1 1
25882526 10.1016/j.bmc.2015.03.060 GABA transporter 2 1
25882526 10.1016/j.bmc.2015.03.060 GABA transporter 3 1
25882526 10.1016/j.bmc.2015.03.060 GABA transporter 4 1

Data from ChEMBL 36 via Core Engine