Compound Detail
CHEMBL3414949
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Basic Information
| ChEMBL ID | CHEMBL3414949 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OOGDWWCJEPHBDQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
193.2
MW (Da)
1.03
ALogP
2
HBA
3
HBD
83.5
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 5.22 | 5.16 | 6000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 6000.0 | nM | 5.22 | Inhibition of human MetAP1b F309M mutant using Met-pNA as substrate | 25699713 |
| Unchecked | Ki | = | 7900.0 | nM | 5.1 | Inhibition of Streptococcus pneumoniae MetAP1a using Met-pNA as substrate | 25699713 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25699713 | 10.1021/jm501790e | Unchecked | 4 |
| 25699713 | 10.1021/jm501790e | Methionine aminopeptidase 1 | 1 |
Data from ChEMBL 36 via Core Engine