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Compound Detail

CHEMBL3415777

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CN(C)CCCOc1ccc(CNc2ccc3nc(N)nc(N)c3c2)cc1

Basic Information

ChEMBL ID CHEMBL3415777
Phase Preclinical
Structure Type MOL
InChI Key HCOMYYWDAFAFSY-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

366.5
MW (Da)
2.74
ALogP
7
HBA
3
HBD
102.3
PSA (Ų)
0.53
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H26N6O
MW 366.47
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.23

Activity Summary

IC50 1 meas. best 5.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
No relevant target
CHEMBL2362975
IC50 5.2 5.2 6380.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
No relevant target IC50 = 6380.0 nM 5.2 Antioxidant activity assessed as inhibition of ABTS free radical scavenging acti... 25899334

Literature References

PubMed DOI Target Context # Activities
25899334 10.1016/j.ejmech.2015.04.028 Trypanosoma cruzi 2
25899334 10.1016/j.ejmech.2015.04.028 Plasmodium berghei 2
25899334 10.1016/j.ejmech.2015.04.028 Leishmania mexicana 1
25899334 10.1016/j.ejmech.2015.04.028 Vero 1
25899334 10.1016/j.ejmech.2015.04.028 No relevant target 1

Data from ChEMBL 36 via Core Engine