Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3416860

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cc1c(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccccc2n1Cc1ccccc1

Basic Information

ChEMBL ID CHEMBL3416860
Phase Preclinical
Structure Type MOL
InChI Key MJFFSDYJUCUECB-UHFFFAOYSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

436.6
MW (Da)
5.66
ALogP
3
HBA
0
HBD
34.5
PSA (Ų)
0.42
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H28N2O2
MW 436.56
Aromatic Rings 4
Heavy Atoms 33
NP-Likeness -0.73

Activity Summary

Ki 4 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1a receptor
CHEMBL1889
Ki 8.7 8.7 2.0 2
Vasopressin V1a receptor
CHEMBL3414410
Ki 6.68 6.68 210.0 1
Vasopressin V2 receptor
CHEMBL1790
Ki 5.03 5.03 9308.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25654260 10.1021/jm501745f Vasopressin V1a receptor 3
25654260 10.1021/jm501745f No relevant target 2
25654260 10.1021/jm501745f Oxytocin receptor 1
25654260 10.1021/jm501745f Vasopressin V2 receptor 1
28001064 10.1021/acs.jmedchem.6b01437 Vasopressin V1a receptor 1

Data from ChEMBL 36 via Core Engine