Compound Detail
CHEMBL34182
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Basic Information
| ChEMBL ID | CHEMBL34182 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VMYSWDNNDBESMT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
427.5
MW (Da)
4.05
ALogP
8
HBA
0
HBD
76.9
PSA (Ų)
0.48
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL250 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 20.0 | nM | 7.7 | Inhibition of [3H]PAF receptor binding to washed human platelet membranes determ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80006-2 | Platelet-activating factor receptor | 1 |
| - | 10.1016/S0960-894X(00)80006-2 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine