Compound Detail
CHEMBL3421844
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Basic Information
| ChEMBL ID | CHEMBL3421844 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WAEYURGKDVTCPM-IAZYJMLFSA-N |
1
Targets
7
Activities
2
Assay Types
1
PK Parameters
6
Publications
0
Known Names
Molecular Properties
303.3
MW (Da)
1.78
ALogP
4
HBA
2
HBD
67.2
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.33
EC50 3 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | EC50 | 8.92 | 8.92 | 1.2 | 3 |
| Somatostatin receptor type 4 CHEMBL1853 | Ki | 7.33 | 7.33 | 46.2 | 4 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 2.167 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | EC50 | = | 1.2 | nM | 8.92 | Agonist activity at human somatostatin 4 receptor expressed in H4 cells assessed... | 25699156 |
| Somatostatin receptor type 4 | EC50 | = | 1.2 | nM | 8.92 | AMP Assay with Human Somatostatin 4 Receptor: The activation of the SSTR4 recept... | - |
| Somatostatin receptor type 4 | EC50 | = | 1.2 | nM | 8.92 | cAMP ASSAY: The activation of the SSTR4 receptor (Gi coupled) causes an inhibiti... | - |
| Somatostatin receptor type 4 | Ki | = | 46.2 | nM | 7.33 | Displacement of [3-125l-Tyr]-somatostatin-(1 -14) from human recombinant somatos... | 25699156 |
| Somatostatin receptor type 4 | Ki | = | 46.2 | nM | 7.33 | Radiogland Binding Assays: For the binding experiments 200 μL of membrane homoge... | - |
| Somatostatin receptor type 4 | Ki | = | 46.2 | nM | 7.33 | Radioligand Binding Assay: Receptor binding assays refer to a technique in which... | - |
| Somatostatin receptor type 4 | Ki | = | 46.2 | nM | 7.33 | Radioligand Binding Assays: Receptor binding assays refer to a technique in whic... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25699156 | 10.1021/ml500538a | Somatostatin receptor type 4 | 2 |
| 25699156 | 10.1021/ml500538a | Liver microsome | 1 |
| 25699156 | 10.1021/ml500538a | Somatostatin receptor type 5 | 1 |
| 25699156 | 10.1021/ml500538a | Somatostatin receptor type 3 | 1 |
| 25699156 | 10.1021/ml500538a | Somatostatin receptor type 2 | 1 |
| 25699156 | 10.1021/ml500538a | Somatostatin receptor type 1 | 1 |
Data from ChEMBL 36 via Core Engine