Compound Detail
CHEMBL3426635
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC[C@H](C)OC(=O)c1ccc(F)c(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1
Basic Information
| ChEMBL ID | CHEMBL3426635 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DIAWPSYORZPEDR-SFHVURJKSA-N |
2
Targets
3
Activities
2
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
558.6
MW (Da)
5.95
ALogP
6
HBA
3
HBD
123.4
PSA (Ų)
0.22
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.26
EC50 1 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 2 CHEMBL2973 | IC50 | 8.26 | 7.7 | 5.5 | 2 |
| Unchecked CHEMBL612545 | EC50 | 7.3 | 7.3 | 50.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.65 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 2 | IC50 | = | 5.5 | nM | 8.26 | Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infecte... | 25898023 |
| Unchecked | EC50 | = | 50.0 | nM | 7.3 | Inhibition of ROCK-catalysed MLC Thr18/Ser19 phosphorylation in rat A7r5 cells a... | 25898023 |
| Rho-associated protein kinase 2 | IC50 | = | 72.0 | nM | 7.14 | Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infecte... | 25898023 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25898023 | 10.1021/acs.jmedchem.5b00308 | Rho-associated protein kinase 2 | 2 |
| 25898023 | 10.1021/acs.jmedchem.5b00308 | Unchecked | 1 |
| 25898023 | 10.1021/acs.jmedchem.5b00308 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine