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Compound Detail

CHEMBL344218

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C[C@@]12CCCc3coc(c31)C(=O)c1cc3c(cc12)C(=O)/C(=N/CCS(=O)(=O)O)C=C3O

Basic Information

ChEMBL ID CHEMBL344218
Phase Preclinical
Structure Type MOL
InChI Key MHNKCROOXKIGJA-MWLMUJSGSA-N
0
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

441.5
MW (Da)
2.89
ALogP
7
HBA
2
HBD
134.2
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C22H19NO7S
MW 441.46
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness 1.78

Activity Summary

IC50 2 meas.

Literature References

PubMed DOI Target Context # Activities
7473578 10.1021/jm00022a016 HCT-116 1
7473578 10.1021/jm00022a016 XRS6 1
7473578 10.1021/jm00022a016 DNA topoisomerase II 1
7473578 10.1021/jm00022a016 Unchecked 1

Data from ChEMBL 36 via Core Engine