Compound Detail
CHEMBL345046
TETRAPHENYLPORPHYRIN Enter ChEMBL ID:
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C1=Cc2nc1c(-c1ccccc1)c1nc(c(-c3ccccc3)c3ccc([nH]3)c(-c3ccccc3)c3ccc([nH]3)c2-c2ccccc2)C=C1
Basic Information
| ChEMBL ID | CHEMBL345046 |
| Name | TETRAPHENYLPORPHYRIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AQPPOLXYUQPDOD-LWQDQPMZSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
614.8
MW (Da)
11.32
ALogP
2
HBA
2
HBD
57.4
PSA (Ų)
0.21
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.0
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ScN2a | IC50 | = | 10.0 | nM | 8.0 | Inhibition of PrP-res formation in mouse ScN2a cells relative to control | 16987659 |
| Unchecked | IC50 | = | 320.0 | nM | 6.5 | Inhibition of PrP-res formation in prion Fukuoka1 strain infected mouse N2a#58 c... | 16987659 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-007-9007-x | NON-PROTEIN TARGET | 3 |
| 23639546 | 10.1016/j.bmcl.2013.03.126 | A549 | 2 |
| 11741471 | 10.1021/jm010246u | Telomerase reverse transcriptase | 1 |
| 16987659 | 10.1016/j.bmcl.2006.08.115 | ScN2a | 1 |
| 16987659 | 10.1016/j.bmcl.2006.08.115 | Unchecked | 1 |
| 19233650 | 10.1016/j.bmcl.2009.02.005 | Bel-7402 | 1 |
| 19233650 | 10.1016/j.bmcl.2009.02.005 | MCF7 | 1 |
| - | 10.1007/s00044-007-9007-x | No relevant target | 1 |
| 23245573 | 10.1016/j.bmc.2012.11.032 | Colon 26 | 1 |
Data from ChEMBL 36 via Core Engine