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Compound Detail

CHEMBL345768

THIOURACIL
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O=c1cc[nH]c(=S)[nH]1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL345768
Name THIOURACIL
Phase Preclinical
Structure Type MOL
InChI Key ZEMGGZBWXRYJHK-UHFFFAOYSA-N

Known Names

2-thiouracil NSC-19473 Thiouracil
0
Targets
2
Activities
2
Assay Types
0
PK Parameters
20
Publications
3
Known Names

Molecular Properties

128.2
MW (Da)
0.43
ALogP
2
HBA
2
HBD
48.6
PSA (Ų)
0.50
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -racil; -uracil

Extended Properties

Molecular Formula C4H4N2OS
MW 128.16
Aromatic Rings 1
Heavy Atoms 8
NP-Likeness -0.53

Activity Summary

EC50 1 meas.
IC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
8978847 10.1021/jm9605243 Mus musculus 12
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
7120285 10.1021/jm00350a014 Mus musculus 6
20921305 10.1128/aac.01029-10 Bacillus anthracis 3
7120285 10.1021/jm00350a014 S91 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
21189019 10.1021/jm101266s Polyunsaturated fatty acid 5-lipoxygenase 1
32283298 10.1016/j.ejmech.2020.112275 Tyrosinase 1
21189019 10.1021/jm101266s Stromelysin-1 1
21189019 10.1021/jm101266s 72 kDa type IV collagenase 1
21189019 10.1021/jm101266s Matrix metalloproteinase-9 1
21189019 10.1021/jm101266s Lethal factor 1
20921305 10.1128/aac.01029-10 J774.A1 1
20020916 10.1080/15376510701857262 Phospholipidosis 1
21189019 10.1021/jm101266s Neutrophil collagenase 1
23750455 10.1021/jm400575x Caco-2 1
21189019 10.1021/jm101266s Tyrosinase 1
18834112 10.1021/jm800656v Amine oxidase [flavin-containing] B 1

Data from ChEMBL 36 via Core Engine