Compound Detail
CHEMBL346290
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL346290 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KLNLNTKIKMROQI-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
462.5
MW (Da)
5.17
ALogP
7
HBA
0
HBD
93.1
PSA (Ų)
0.39
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.01
IC50 1 meas. best 5.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | EC50 | 8.01 | 8.01 | 9.8 | 1 |
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 5.79 | 5.79 | 1621.8 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 100.0 | ng.hr.mL-1 | Canis lupus familiaris |
| CL | 31.17 | mL.min-1.kg-1 | Canis lupus familiaris |
| F | 15.2 | % | Canis lupus familiaris |
| T1/2 | 0.9 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | EC50 | = | 9.8 | nM | 8.01 | Effective concentration required for inhibition of farnesylation of Ras protein ... | 14736242 |
| Protein farnesyltransferase | IC50 | = | 1621.81 | nM | 5.79 | Inhibition of FTase | 16455255 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14736242 | 10.1021/jm030434f | Canis familiaris | 4 |
| 14736242 | 10.1021/jm030434f | Protein farnesyltransferase | 2 |
| 14736242 | 10.1021/jm030434f | Geranylgeranyl transferase type I | 1 |
| 16455255 | 10.1016/j.bmcl.2006.01.019 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine